Dr. Sheng has also servedon the editorial board of Journal of Cell Biology (JCB) and Journal of Biological Chemistry (JBC) and associate editor of Autophagy. Discover remarkable stories of scientific progress, and explore the intersections of science, medicine, and society. His Ph.D. thesis was completed at Harvard Medical School in the lab of Michael Greenberg. In the past few years, Pan has been working on genes whose dysfunction has been implicated for psychiatric illnesses using molecular, cellular, and electrophysiological approaches, both in vitro and in animals. All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. The Broad Institute of MIT and Harvard is looking for an exceptional candidate to join the Sheng lab or the Therapeutics group (led by Professor Morgan Sheng) in the Stanley Center for Psychiatric. The role will often involve rapid prototyping in support of a dynamic, fast-moving experimental program; it is focused on molecular biology applications relevant to investigation of brain function and psychiatric illness. Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. Broad Institute 4.0. Sheng and coworkers made important discoveries regarding the molecular mechanisms of synapse weakening and loss, the contributions of microglia and innate immunity in neurodegenerative diseases, and the roles of genetic risk factors in the pathogenesis of Alzheimers disease, Parkinsons disease, ALS, and frontotemporal dementia. Sheng is a fellow of the Royal Society (UK), a fellow of the Academy of Medical Sciences (UK), a fellow of the American Association for the Advancement of Science, and honorary fellow of Corpus Christi College, Oxford. Additionally, developing new . It requires basic molecular biology expertise and laboratory equipment, including . In a new study published in Oncogenesis, Zhi Sheng and Rob Gourdie of the Fralin Biomedical Research Institute at VTC describe how two protein-targeting drugs - when combined with chemotherapy - yield synergistic cytotoxicity to treatment-resistant glioblastoma. and sequencing, takes ~3 d to process up to 192 samples manually. Fralin Biomedical Research Institute faculty conduct research in wet and dry labs in our 280,000-square-foot facilities . Dr. Sheng lab haspublisheda number of important studies focused on axonal transport of mitochondria and endolysosomes in healthy and diseased neurons. Currently, the Sheng lab focuses on three areas of research: Immune response to infection and vaccination: We develop computational methods to study immune responses . . About the Lab. Ben joined the Engreitz Lab at the Broad Institute to develop experimental and computational tools to study enhancers and noncoding GWAS variants at single-cell resolution. Following postdoctoral research in the lab of Lily Jan at the University of California, San Francisco, Sheng served as a faculty member in the Department of Neurobiology at Massachusetts General Hospital and Harvard Medical School (1994-2001) before joining MIT (2001-2008). Morgan Sheng Broad Institute of MIT and Harvard Verified email at mit.edu. 3 Broad Institute of MIT and . 1. See popular questions & answers about Broad Institute; Post-Doctoral Associate - Neuroscience Department. Lab website. Learn about breakthroughs from Broad scientists. The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: / b r o d /, pronunciation respelling: BROHD), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it . There he built and led a world-class neuroscience department and research program focused on elucidating pathologic mechanisms and developing new treatments for neurodegenerative diseases and pain, and illuminating pathways that are of basic scientific interest as well as therapeutic relevance. The Sheng lab uses interdisciplinary approaches to elucidate the mechanisms of humoral immune response to infection and to understand the role of B cells in autoimmunity. Mailing address: California Institute of Technology. We are seeking a motivated Computational Associate II (CA) to join the Sheng Lab at the Broad Institute of MIT and Harvard. The Broad Institute of MIT & Harvard is looking for a Research Associate II to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research. is author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. ; 2 Department of Microbiology, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. Requests for exemption for medical or sincerely held religious beliefs will be considered. NE30-6031. Morgan Sheng Core Institute Member, Broad Institute of MIT and Harvard Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute Professor of Neuroscience, Department of Brain and Cognitive Sciences Affiliate Member, The Picower Institute for Learning and Memory Affiliate Member, McGovern Institute for Brain Research The four magnified images on the right show how the cell takes up the treatment across a span of 30 seconds. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery. Published by at July 3, 2022. He is affiliated with the Department of Electrical and Computer Engineering, Carle Illinois College of Medicine, Beckman Institute, and the Department of Bioengineering. Dr. Sheng received the 2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The . Jin Sheng's Employment details. In Situ Biology Join Us Contact The Chen Lab. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to shape the center's scientific vision and direction, and oversee the center's efforts to develop therapeutics for schizophrenia and other serious mental illnesses. Postdoctoral Associate - Sheng Lab Broad Institute of MIT and Harvard Cambridge, MA 1 month ago Be among the first 25 applicants jleonard@caltech.edu. In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity. Consistently, TCGA data analysis shows an inverse correlation between LSD1 expression and CD8 + T cell infiltration in various human cancers. Blainey Lab Golub Lab Hung Lab Lander Lab Liu Lab Regev Lab Schreiber Lab Sellers Lab Xavier Lab Zhang Lab Institute Member labs Eric Alm, MIT Paola Arlotta, Harvard Picower Professor of Biology and Neuroscience; Director, RIKEN-MIT Laboratory for Neural Circuit Genetics. sheng lab broad institute Isotianil is a monocarboxylic acid amide that has been used as a fungicide to control rice blast and could potentially induce systemic . Broad Institute 4.0. . Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research. By the end of 2022, Broads COVID-19 testing lab had processed more than 37 million tests. Neurobiologist and drug developer returns to academia to help guide the Broads psychiatric research. AY Hung, M Sheng. Research Areas . Massachusetts Institute of Technology 43 Vassar Street, Bldg. The Sheng lab is a highly collegial and collaborative environment consisting of postdocs and graduate students who have the freedom to pursue a broad range of projects in the areas. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research and as a professor of . Fellow of the Royal Society (FRS), London, UK (elected 2007), Fellow of the Academy of Medical Sciences (UK) (elected 2009), Honorary Fellow, Corpus Christi College, Oxford (elected 2010), Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimers disease, Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies, Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation, TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia, Researchers map brain cell changes in Alzheimers disease. The Stanley Center engages in large-scale, globally conducted studies of . The Broad faculty consists of Institute Members and Associate Members. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. Cristea Lab Department of Molecular Biology 210 Thomas Laboratory Washington Road Princeton, NJ 08544 p 609-258-9425. The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa. Shengs molecular studies of the structure and function of synapses (the communication junctions between brain cells) while at MGH and MIT have enhanced our understanding of the neural basis of cognitive function and dysfunction, including learning and memory, neurodevelopmental disorders, and dementia. Sheng completed his medical training and a residency in general medicine in London, UK. The successful candidate will join a multidisciplinary group and perform cutting-edge basic and/or translational research on the molecular, cellular and neurobiological mechanisms of psychiatric disorders, especially in relation to risk genes for schizophrenia and bipolar disorder, synapse development/elimination, synaptic function/plasticity, neuron-glia interactions, and neural circuitry/interneurons. Shengs molecular studies of the structure and function of synapses (the communication junctions between brain cells) while at MGH and MIT have enhanced our understanding of the neural basis of cognitive function and dysfunction, including learning and memory, neurodevelopmental disorders, and dementia. Laboratory Technician 1,190 job openings. The Chen Lab. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. Massachusetts Institute of Technology - The Broad Institute of MIT and Harvard is looking for an exceptional candidate to join the Sheng lab or the Therapeutics group (led by Professor Morgan Sheng) in the Stanley Center for Psychiatric Research . Avoid inappropriate use of antibacterial drugs, especially the combined use of broad-spectrum antibacterial drugs. Dr. Shengreceived the2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. Sheng J, Gan, J, Soares, A, Salon, J, Huang Z. Identified telomerase isoforms by integrating NGS and RACE data: Designed and performed experiments (RACE) and sequence analyses (bash). Cambridge, MA 02142. He has used a broad range of approaches to tackle these problems, notably the development of neuronal cultures from adult disease . Sheng Lin-Gibson (Fed) Dr. Sheng Lin-Gibson is the Chief of the Biosystems and Biomaterials Division (BBD) at the National Institute of Standards and Technology (NIST). We are a new research lab in the Department of Chemistry and The RNA Institute within the University at Albany, State University of New York (SUNY). Work with other Broad computational biologists, including those in the Levin group to learn, discuss, and integrate the most appropriate solution for an experiment or project. He is also. Posted: December 20, 2022. Learn about breakthroughs from Broad scientists. Many of their ongoing projects are multidisciplinary, bridging engineering with materials science, chemistry, and life sciences. Find our contact information, directions to our buildings, and directory. Combining cutting-edge technologies from structural biophysics, molecular engineering, and translational . Jiaoti Huang, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., 13-229 CHS . Receive regular updates on Broad news, research and community. He obtained his B.S. . (1st class honors) from Oxford University and obtained his medical degree and training at London University. Lab Administrator. Biological products exc.diagnostic Umbilical cord blood stem cells and collection, storage, should be the technical services and research and development) Sheng laboratory focuses on mechanisms regulating axonal transport that is essential for the maintenance of synaptic function and axonal homeostasis. Nathaniel earned his MA in psychology from Boston University in 2022 William Ned Martenis is a therapeutics group research associate affiliated with the Pan and Sheng labs, where he primarily develops, troubleshoots, and runs high-throughput assays designed to better Kate graduated from American University in 2016 with a BA in Psychology. I am currently an Associate Computational Biologist II in the Morgan Sheng lab at the Broad Institute of MIT and Harvard. In November 2022, Broads Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. Dr. Fei Chen is currently a Core Faculty member at the Broad Institute, and assistant professor at Harvard Stem Cell and Regenerative Biology. Here, we report a single-molecule approach capable of . We join with institutions and scientists the world over to address foundational challenges in science and health. Learn about Broad Institute's mentored research offerings for high school students, college students, and recent college graduates. - Investigating stem cells, regeneration and ageing using Planarian flatworms. The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of theStanley Center for Psychiatric Research, The mission of the Stanley Center is to improve the lives of patients suffering from serious mental illnesses, through groundbreaking basic and translational research. He has served on the editorial boards of Neuron, Journal of Neuroscience, and Current Opinions in Neurobiology. Learn about our mission, leadership, history, and partner institutions. Research. Correlating atomic configurationsspecifically, degree of disorder (DOD)of an amorphous solid with properties is a long-standing riddle in materials science and condensed matter physics . The Broad Institute of MIT and Harvard is looking for an exceptional candidate to join the Sheng lab or the Therapeutics group (led by Professor Morgan Sheng) in the Stanley Center for Psychiatric Research . Feb 2023 - Present2 months. Zizhang Sheng is an associated research scientist in the Honig-Shapiro labs. In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. Get alerts to jobs like this, to your inbox. Lab studies the genetics underlying neural development to identify new diagnostic and therapeutic approaches for a broad range of disorders that compromise brain and organ system development. Virginia Tech Carilion Research Institute scientists have developed new imaging techniques to watch dangerous brain tumor cells respond to treatment in real time. Standing could determine the Supreme Court ruling. (1st class honors) from Oxford University and obtained his medical degree and training at London University. 10:45-11:45 - SESSION 2 - DEVELOPMENT & PLASTICITY. . Excited & proud to share the work of #PeijunMa, a longtime friend & collaborator who led (in #DebHung 's lab . An official website of the United States government, Assistant Clinical Investigators (ACI) and Independent Research Scholar (IRS), NINDS BEACON Program - Building Engagement and Community for Nurses, Office of Research Training & Career Development, Lab Research Highlighted in NIH Press and Journals. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. Dr. Pan has more than 15 years of experience investigating the function, molecular genetics and pharmacology of ion channels. Visit our free public educational space that showcases how researchers at the Broad and their colleagues around the world seek to understand and treat human disease. Pursuing these investigations will advance our knowledge of fundamental processes that may affect human neurological disorders. Copyright Pentagram. 2012 - 2017 Ershela Durresi, Ph.D. Medical Student, Harvard Medical School . We are currently located in this beautiful Life Science Research Building at the main campus. The mission of the Stanley Center is to improve the lives of patients suffering from serious mental illnesses, through groundbreaking basic and translational research. Explore the connection between art and science and how we bring together artists and Broad scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations. Requests for exemption for medical or sincerely held religious beliefs will be considered. By the end of 2022, Broads COVID-19 testing lab had processed more than 37 million tests. We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries. The research of her group focuses on translating emerging genetics into biology and to enable next-generation . All Rights Reserved. . Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries. 617-253-6459. This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community. Cambridge, MA. Researchers in the Sheng . Access free classroom materials and more for STEM educators, parents, students, tutors, and others. (1st class honors) from Oxford University and obtained his medical degree and training at London University. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery. Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research.He will also return to MIT, after a decade in industry, as a professor of neuroscience in the Department of Brain and . Postdoctoral Associate - Sheng Lab. In November 2022, Broads Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. Sheng spent the past 10 years at Genentech, a preeminent biotech company, as Vice-President of Neuroscience. Currently, the Sheng lab focuses on three areas of research: Immune response to infection and vaccination: We develop computational methods to study immune responses of humans and animal models.

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